Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1
Abstract
A 42-base pair sequence from the 5' flanking region of the low density lipoprotein receptor gene was shown previously to confer sensitivity to sterol-mediated repression when inserted into the herpes simplex virus thymidine kinase promoter. This sequence contains two contiguous 16-base pair repeats, …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
cell line
DNA
genetic*
plasmids
DNA-Binding Proteins / metabolism*
Receptors
Transcription Factors / metabolism*
Base Sequence
mutation
Promoter Regions
Messenger / genetics
transcription
gene expression regulation / drug effects*
nucleic acid
cricetinae
repetitive sequences
transfection
binding sites
base composition
pmid:3277969
p a dawson
s l hofmann
j l goldstein
recombinant
ldl / genetics*
sp1 transcription factor
sterols / pharmacology*
thymidine kinase / genetics
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265994
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