ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Yueh-Lin Tsai, Tristan H. Coady, Lei Lu, Dinghai Zheng, Isabel Alland, Bin Tian, Neil A. Shneider, James L. Manley;Yueh-Lin Tsai;Tristan H. Coady;Lei Lu;Dinghai Zheng;Isabel Alland;Bin Tian;Neil A. Shneider;James L. Manley;
genes & development 2020 Vol. 34 pp. 785-
149
manley2020genesals/ftd-associated

Abstract

Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular ...

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