ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs
Yueh-Lin Tsai, Tristan H. Coady, Lei Lu, Dinghai Zheng, Isabel Alland, Bin Tian, Neil A. Shneider, James L. Manley;Yueh-Lin Tsai;Tristan H. Coady;Lei Lu;Dinghai Zheng;Isabel Alland;Bin Tian;Neil A. Shneider;James L. Manley;
genes & development2020Vol. 34pp. 785-
149
manley2020genesals/ftd-associated
Abstract
Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular ...