synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti-angiogenesis activities
Abstract
A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
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251381
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0x95644003c57E6F55A65596E3D9Eac6813e3566dA
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251381
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10.3390/molecules19078916
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Scimatic Chain (ID: 481)
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