The article reveals problems and directions of establishment of responsibility of business in Ukraine for successful, sustainable and long-term interaction of entrepreneurship, power and society. The article conducts graphic-analytical analysis of advantages of implementation of the responsibility strategy, which allowed a conclusion that more than two thirds of Ukrainian enterprises believe that social responsibility measures exert influence upon possibilities of an organisation to find and keep best workers, formation of a positive image and improvement of reputation and creation of competitive advantages. The article shows that development of corporate social responsibility has just started its development in Ukraine. That is why, the majority of domestic enterprises face the task of achieving the economic side of this responsibility. Which means that partnership programmes of support of society, social investments and charity should become the basis of social responsibility. The article offers to distribute the sphere of application of social responsibility, namely: companies should transform corporate social responsibility upon corporate social benefit. Mentality of social entrepreneurship is capable of assisting even major enterprises in finding new markets, new services in existing markets and expansion of the existing markets. Solution of social and ecological problems in partnership with the power and public organisations constitutes certain possibilities for sustainable development of an enterprise.