Objectives: Findings Demonstrated that Parent of Children With Cerebral Palsy Experience Elevated Level of Distress, Depression, Anxiety, Posttraumatic Stress Symptom and Subjective Symptom of Stress. Depression is a common condition that typically has a relapsing course. Effective interventions targeting relapse have the potential to dramatically reduce the point prevalence of the condition. Many of studies have shown that Mindfulness based cognitive therapy (MBCT) is an intervention that has shown efficacy in reducing Depression syndrome and depressive relapse. In This Study, Effectiveness of Mindfulness–Based Cognitive Therapy (MBCT) on Reduction of Depression in Mothers of Children with Cerebral Palsy was examined. Methods: Three Mothers Whose Children Had Cerebral Palsy Were Diagnosed to Have Depression Symptoms, Using Beck Depression Inventory II, Structured Clinical in This Experimental Signal–Case Study. After The Baseline was Determined, Subject Attended on Eight–Session Program of Mindfulness–Based Cognitive Therapy. Results: The Comparison of Baseline and Post–Test was Showed That Depression Symptom has decreased through MBC. Improvement Quotient for Depression of each Subject was good. Discussion: Data Showed that MBCT Reduced Depression Symptoms in Mothers of Children With Cerebral Palsy.