Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
Abstract
The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1alpha [HNF1alpha], -1beta, -3alpha, -3beta, -3gamma, -4alpha, and -6 and members of the c/eb …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
phenotype
Receptors
Transcription Factors / metabolism*
Base Sequence
Active
Y H Lee
Liver / metabolism*
Knockout
cell differentiation
lipid metabolism*
transcription factors / genetics
homeostasis
gene expression*
dna-binding proteins*
pmid:11158324
pmc99591
doi:10.1128/mcb.21.4.1393-1403.2001
g p hayhurst
f j gonzalez
basic helix-loop-helix leucine zipper transcription factors
bile acids and salts / metabolism
biological transport
dna primers / genetics
gene targeting
hepatocyte nuclear factor 4
hepatomegaly / genetics
hepatomegaly / pathology
lipids / blood
liver / cytology
liver glycogen / metabolism
phosphoproteins / genetics
phosphoproteins / metabolism*
cytoplasmic and nuclear / genetics
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Citation
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117390
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