PPAR gamma is required for placental, cardiac, and adipose tissue development
Abstract
The nuclear hormone receptor PPAR gamma promotes adipogenesis and macrophage differentiation and is a primary pharmacological target in the treatment of type II diabetes. Here, we show that PPAR gamma gene knockout results in two independent lethal phases. Initially, PPAR gamma deficiency interferes …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
RNA
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Genes
Receptors
Liver / pathology
Knockout
adipose tissue / growth & development*
gene targeting / methods
in situ hybridization
messenger / metabolism
cytoplasmic and nuclear / genetics*
cytoplasmic and nuclear / metabolism
transcription factors / genetics*
transcription factors / metabolism
nuclear proteins / metabolism
developmental
cell differentiation / genetics
fetal viability / genetics
reporter
nuclear proteins / genetics
pmid:10549290
doi:10.1016/s1097-2765(00)80209-9
y barak
m c nelson
r m evans
heart / growth & development*
lipodystrophy / genetics
myocardium / cytology
myocardium / ultrastructure
placenta / cytology
placenta / ultrastructure
placentation*
ploidies
retinoic acid / genetics
retinoid x receptors
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Citation
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117001
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