Prognostic impact of low allelic ratio FLT3- ITD and NPM1 mutation in acute myeloid leukemia
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Prognostic impact of low allelic ratio FLT3- ITD and NPM1 mutation in acute myeloid leukemia

Sakaguchi M;Yamaguchi H;Najima Y;Usuki K;Ueki T;Oh I;Mori S;Kawata E;Uoshima N;Kobayashi Y;Kako S;Tajika K;Gomi S;Shono K;Kayamori K;Hagihara M;Kanda J;Uchiyama H;Kuroda J;Uchida N;Kubota Y;Kimura S;Kurosawa S;Nakajima N;Marumo A;Omori I;Fujiwara Y;Yui S;Wakita S;Arai K;Kitano T;Kakihana K;Kanda Y;Ohashi K;Fukuda T;Inokuchi K;;
blood advances 2018 Vol. 2 pp. -
481
m2018bloodprognostic

Abstract

In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)-positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopo …

Keywords

leukemia National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine prognosis adult female male adolescent aged middle aged young adult 80 and over Retrospective Studies mutation Nuclear Proteins / genetics* hiroki yamaguchi pmid:30341082 pmc6199656 doi:10.1182/bloodadvances.2018020305 masahiro sakaguchi koiti inokuchi myeloid acute / genetics* acute / pathology nuclear proteins / metabolism fms-like tyrosine kinase 3 / genetics*

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